Reshmi Buthello

Head of People & Culture at Main Sequence + 5B

Reshmi Buthello is Head of People & Culture at Main Sequence and 5B, where she supports novel tech ventures through scale, maturity, and culture building. With global experience across large tech and early-stage companies, Reshmi brings strategic clarity, talent insight, and an investor mindset to her People practice. She’s passionate about helping teams build the internal capability and leadership edge that growth demands.

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The People & Culture edge: Building investable companies through people, culture & leadership

What makes a company truly investable? In this panel, Melanie Robb, Erika Enberg, Jess Blomfield, and Reshmi Buthello bring investor and operator perspectives to the people, culture, and leadership traits that signal growth readiness. Reshmi draws from her experience with deep tech scale-ups at Main Sequence and 5B; Erika from nearly two decades guiding startups from seed to Series E; Jess from her work with ANZ's leading startups at Airtree Ventures; and Melanie from advising early-stage founders through her people-first, scale-ready frameworks at avviare. Together, they’ll explore the fundamentals investors notice, the red flags they don’t ignore, and how People leaders can align talent, culture, and strategy for long-term success. This is for anyone building from the inside—and thinking like an investor.

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SPS Speaker Headshot: Reshmi Buthello

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Post event ADD-ONS

Catch up on what you missed, and keep the conversations going

With five tracks running across the first‑ever Startup People Summit, even the most committed note‑takers couldn’t catch it all live.

Now, you don’t have to miss a thing.

The SPS 2025 On‑Demand channel is ready. Packed with 40+ session recordings from every track, game‑changing ideas from all our speakers, and 12 months to watch, rewatch, and take notes at your own pace.

But SPS was never just an event. With the All Access Bundle, you’ll get everything in On‑Demand, plus join our new private SPS Community—a year‑round space where startup People professionals share challenges and wins in real time, swap fresh ideas and frameworks, collaborate on solutions, and know they’re not doing this work alone. Because the real value of SPS isn’t just in what we heard, it’s in what we can build together next.

Just a reminder: If you’re a Unicorn Pass holder, you already have On‑Demand and SPS Community access included. No need to purchase an add‑on — you’re already all set!

ADD-ON

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