Reshmi Buthello

Head of People & Culture at Main Sequence + 5B

Reshmi Buthello is Head of People & Culture at Main Sequence and 5B, where she supports novel tech ventures through scale, maturity, and culture building. With global experience across large tech and early-stage companies, Reshmi brings strategic clarity, talent insight, and an investor mindset to her People practice. She’s passionate about helping teams build the internal capability and leadership edge that growth demands.

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The People & Culture edge: Building investable companies through people, culture & leadership

What makes a company truly investable? In this panel, Reshmi Buthello, Erika Enberg, Jess Blomfield and Melanie Robb bring investor and operator perspectives to the people, culture, and leadership traits that signal growth readiness. Reshmi draws from her experience with scale-ups and deep tech ventures at Main Sequence and 5B, Erika from nearly two decades guiding startups from seed to Series E, and Jess from her work with ANZ's leading startups at Airtree Ventures. Together, they’ll explore the fundamentals investors notice, the red flags they don’t ignore, and how People leaders can align talent, culture, and strategy for long-term success. This is for anyone building from the inside—and thinking like an investor.